Name | Pimafucin |
Synonyms | PIMARICIN Pimaricin Pimafucin PIMAFUCIN Natamycin NATAMYCIN antibiotica-5283 natamycin sterile Natamycin(FermentionProcess) PIMARICIN, STREPTOMYCES CHATTANOOGENSIS Pimaricin, Streptomyces chattanoogensis (1.07360) NataMycin, A 5283, Delvolan, Delvocid, Myprozine, Natacyn, Natafucin, PiMafucin, PiMafugin, A5263, CL 12625, E235 22-[(3-amino-3,6-dideoxy-beta-D-glycero-hexopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0~5,7~]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid (8Z,14Z,16Z,18Z,20Z)-22-[(3-amino-3,6-dideoxyhexopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0~5,7~]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid (1R,3S,5R,7R,8E,12R,22R,24S,25R,26S)-22-[(3-amino-3,6-dideoxy-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0~5,7~]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0~5,7~]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid (1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-22-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid |
CAS | 7681-93-8 |
EINECS | 231-683-5 |
InChI | InChI=1/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6-,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32?,33-/m1/s1 |
InChIKey | NCXMLFZGDNKEPB-FFPOYIOWSA-N |
Molecular Formula | C33H47NO13 |
Molar Mass | 665.73 |
Density | 1.0g/mLat 20°C(lit.) |
Melting Point | 2000C (dec) |
Boling Point | 952℃ |
Specific Rotation(α) | D20 +278° (c = 1 in CH3COOH) |
Flash Point | >110°(230°F) |
Water Solubility | 0.41g/L(21 ºC) |
Solubility | Several insoluble in water, slightly soluble in methanol, soluble in glacial acetic acid and dimethyl sulfoxide |
Vapor Presure | 0mmHg at 25°C |
Appearance | White to creamy yellow crystalline powder |
Color | Cream colored |
Merck | 13,6453 |
BRN | 1614878 |
pKa | pKa 4.6(50% aq. MeOEtOH) (Uncertain);8.35 (Uncertain) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Stability | Light sensitive |
Sensitive | Light Sensitive |
Refractive Index | 1.5960 (estimate) |
MDL | MFCD00135085 |
Physical and Chemical Properties | Almost white to cream-yellow powder, almost odorless and tasteless. It may contain 3mol of water. Melting point 280 °c (decomposition). A few do not dissolve in water, methanol-soluble, soluble in glacial acetic acid and dimethyl sulfoxide. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. |
WGK Germany | 2 |
RTECS | TK3325000 |
FLUKA BRAND F CODES | 8-10 |
HS Code | 29419090 |
Toxicity | LD50 orally in male, female rats (g/kg): 2.73, 4.67 (Levinskas) |
Reference Show more | 1. Chen Yuchao Liu Shuyun Feng Yingpeng et al. Determination of natamycin residue in fresh juice of Dendrobium by RP-HPLC [J]. Food Industry 2019 40(03):273-276. 2. Li Xuehong, Wu zonshuai, Lu Yong, etc. Study on the inclusion of natamycin and macrodextrin [J]. Science and Technology of Food Industry, 2012, 033(020):112-115. |